Dublin's Cian O'Sullivan and Paul Flynn have been ruled out of the International Rules series with hip problems.
O'Sullivan, who trained with the squad a few weeks ago, has undergone surgery to fix a hip problem, while a similar injury means Flynn won't be boarding the flight to Perth either.
Ireland manager Paul Earley is also planning without the Carlton trio of Ciaran Byrne, Zach Tuohy and Ciaran Sheehan, who have pre-season commitments with the Blues, while recently-retired Wicklow star Leighton Glynn is doubtful due to a thumb injury.
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